Based on the Clinical-Research-Disease Management Integration Platform of Jiangsu Hospital of Traditional Chinese Medicine, this article investigates the risk factors for the progression of patients with chronic kidney disease (CKD) stages 3-5 and the protective effects of traditional Chinese medicine (TCM).A total of 186 patients with CKD stages 3-5 attending the hospital from Mar 1, 2020 to Oct 30, 2023 were collected and grouped according to progression of their renal function, and the risk factors for the progression of the patients' renal function, as well as the effects of traditional Chinese medicine on their renal function, were assessed by logistic regression.Among 186 patients the average estimated glomerular filtration rate (eGFR) reduction rate was about 15.22% and the average eGFR slope was -3.44 mL·(min·1.73 m²）^-1 in the group with progressive renal function, and the average eGFR reduction rate was about 1.02% and the average eGFR slope was 1.33 mL·(min·1.73 m²）^-1 in the group with stable renal function.Logistic regression analysis using whether renal function progressed as the dependent variable and clinical indicators as independent variables showed that combined hypertension, uric acid >420 μmol·L^-1, and albumin <34 g·L^-1 were the risk factors for renal function progression in CKD patients, and age >65 years and taking TCM were the protective factors.Patients were grouped based on the duration of TCM usage.Survival analysis indicated that both the intermittent and continuous TCM usage groups had a higher rate of stable kidney function and higher eGFR compared to the group that did not use TCM.The results demonstrate that in CKD patients with concurrent hypertension, the higher uric acid levels and the lower albumin levels, the higher the risk of kidney function progression.TCM treatment and patients aged 65 and above tend to stabilize kidney function.Continuous and long-term intermittent use of TCM can delay the progression of kidney function deterioration in CKD patients and postpone the need for renal replacement therapy.

chronic kidney disease stages 3-5  /  real world study  /  progression of renal function  /  estimating glomerular filtration rate slope