Osteoarthritis (OA) is the most common degenerative disease of joint, which is characterized by degeneration of articular cartilage and inflammation of articular capsule. Inflammatory reaction of articular cartilage is usually related to oxidative stress and secretion of proinflammatory cytokines in OA microenvironment. This article describes the role of inflammatory reaction in osteoarthritis and discusses the related progress in the treatment of osteoarthritis with cyclooxygenase, interleukin-1, inhibitor, prostaglandin synthetase inhibitor, and antioxidant stress drugs.

osteoarthritis  /  inflammatory reaction  /  cartilage injury  /  oxidative stress  /  anti-inflammatory drugs