Ischemia-reperfusion injury (IRI) is a congenital defect of organ transplantation. Extended criteria donor (ECD) organs are more susceptible to IRI, resulting in a serious contradiction between supply and demand. Although the breakthrough of machine perfusion technology has brought the hope of alleviating IRI, it still cannot eradicate the organ damage caused by IRI. Ischemia-free organ transplantation can completely avoid IRI, improve graft function, improve the prognosis of patients, and expand the source of graft. This article summarizes the latest progress of ischemia-free organ transplantation, and looks forward to the future development of ischemia-free organ transplantation, so as to help researchers and clinicians in related fields understand the latest research status of ischemia-free organ transplantation and provide reference.

ischemia-free organ transplantation（IFOT）  /  normothermic machine perfusion（NMP）  /  ischemia reperfusion injury  /  early allograft dysfunction