Based on the research progress in real-world clinical study and artificial intelligence technology domestically and internationally, aiming at the issues of the concepts, methods, and technologies for conducting high-quality TCM real world clinical research, this article focuses on the challenges and solutions for the transformation of real world research paradigms, the establishment of clinical problem-oriented research models, the quality of real world data, and the methodology of inferring high-quality causal evidences. With a view to fully understanding the importance and difficulty of real world TCM research for the high-quality development of TCM from the ontological perspective of TCM clinical diagnosis and treatment, it is expected to provide reference for establishing a new real-world research system with TCM characteristics and creating a new model of TCM clinical research.

real-world clinical study  /  research paradigm  /  Traditional Chinese Medicine  /  integration of clinical practice and research  /  artificial intelligence