The Nobel Prize in Chemistry 2022 was jointly awarded to Carolyn Ruth Bertozzi, Morten Meldal and Karl Barry Sharpless for the development of click chemistry and bioorthogonal chemistry. Sharpless has won the Nobel Prize in Chemistry for the second time since 2001. This paper reviews his scientific research and achievements in the field of click chemistry, analyzes the characteristics of click chemistry, that is, simplicity and efficiency. Meanwhile, the paper points out that his research direction changing from chiral catalytic oxidation reaction to click chemistry reflects the scientific spirit of selfbreakthrough and never-ending and the interdisciplinarity of his study also reveals the way to cultivate innovative scientists.

Sharpless  /  the Nobel Prize in Chemistry 2022  /  chirally catalysed oxidation reactions  /  click chemistry