COVID-19 has a great impact on human life. After the outbreak of the epidemic, global scientific research institutions and pharmaceutical companies responded quickly and stepped up the research and development of vaccines and antiviral drugs. A series of therapies such as innovative mRNA vaccines, antiviral neutralizing antibodies, and small molecule antiviral drugs emerged. However, with the emergence of a variety of COVID-19 variants, the effectiveness of COVID-19 vaccines, neutralizing antibody and small molecule drugs greatly reduced, which constantly posed new challenges to the development of COVID-19 vaccines and drugs. This article reviews the research and development progress of COVID-19 vaccines and drugs based on literature and commercial database information. By Nov 2022, there had been more than 30 COVID-19 vaccines and more than 30 anti COVID-19 drugs approved or granted EUA, and many vaccines and drugs in clinical trials. China led the world in the research and development of COVID-19 vaccines and anti COVID-19 drugs.

COVID-19  /  virus mutant  /  vaccines  /  neutralizing antibody  /  small molecule antiviral drugs