In order to identify the efficacy of Xiaoer Jianpi Bufei ointment on the treatment of recurrent respiratory tract infection (RRTI) in children and its potential immunology mechanism, children with RRTI admitted to Foshan Fuxing Chancheng hospital from Jan 2019 to Dec 2020 were randomly divided into the combination group of traditional Chinese medicine (TCM) and western medicine (Xiaoer Jianpi Bufei ointment + immunoactive peptide) and control group (immunoactive peptide). Indicators included: the peripheral blood CD3+, CD4+ and CD8+ detected by flow cytometry, maximum expiratory flow (PEF), and TCM syndrome score for RRTI. Subjects were followed up to 1 year after the treatment. The results showed that after the treatment, the levels of CD3+ and CD4+ , PEF, RRTI and TCM syndrome scores of the combination group were significantly higher than those of the control group. During the treatment, the adverse reactions (2.22%) of the combination group were lower than those of the control group (13.33%), and finally the efficacy of the combination group (97.77%) was higher than that of the control group (84.44%). It suggests that the integrated Chinese and western medicines of Xiaoer Jianpi Bufei ointment combined with immunoactive peptide for treatment of children's RRTI can further improve the immune level and expiratory function, and relieve the clinical symptoms, which may improve the clinical safety and efficacy.

integrated Chinese and western medicines  /  recurrent respiratory tract infection in children  /  Xiaoer Jianpi Bufei ointment  /  immune function  /  expiratory function