To achieve the sustainable and high-quality development in the post-epidemic era, it is an important issue for science and technology enterprises to maintain the growth resilience. This paper selects 1907 high-tech enterprises in Nanjing, and in multiple perspectives (e. g., the impact extent, the realistic dilemmas, the policy demands of the normalization of the infection prevention, and the control of COVID-19 in science and technology enterprises) analyzes the actual and potential impacts of the PHEIC. Survey results show that (1) 52.44% science and technology enterprises are deeply affected by the crisis, with the declining revenue as the major challenge and the adverse impact on the new product development as the main barrier for the innovation. (2) In terms of operation, the development of science and technology enterprises is mainly limited by the recruitment of talents, which also leads to the high financial risk. In terms of research and development, the dilemmas appear due to the difficulty in the talent recruitment, the lack of self-help measures in the digitalization and the intelligent transformation, and the high costs of marketing innovative products. (3) There also exists a buffer period for the government's support policies to be fully implemented, which makes the policy demands of the science and technology enterprises unsatisfied. 91.14% of enterprises expect an increase in R&D subsidies. We propose that in the process of the normalization of the epidemic prevention and control, the ways of cultivating and attracting talents for technology enterprises should be updated, and the cooperation of industry, university and research institute should be strengthened. Correspondingly, it is significant to build a dynamic monitoring and technology risk early warning system in the high-tech field f the technology security. Meanwhile, in the reform of the science and technology systems and mechanisms, it is necessary to speed up the construction of the digital government and the scientific and technological innovation environment to promote the science and technology innovation governance system and to modernize the governance capacity.

COVID-19  /  high-tech enterprises  /  sustainable development  /  government policy