With the development of precision medicine, tumor markers have been paid more and more attention by researchers, and their understanding has gradually made a breakthrough. The research content of tumor markers has been gradually expanded to tumor markers based on tumor genome and chromosomal variations, liquid biopsy, epigenetics and metabolomics; moreover, tumor marker-related detection technologies have developed rapidly, including liquid biopsy, high-throughput gene sequencing, single-cell sequencing and other new technologies; furthermore, with the continuous development of these new high-technologies, tumor marker detection has achieved a breakthrough from single detection to multi-factor combined detection; finally, in clinical practice, tumor marker detection has played an important role in early tumor screening and diagnosis, guiding tumor treatment and predicting efficacy as well as predicting tumor recurrence, metastasis and prognosis, which is of great significance to improve the quality of cancer diagnosis and treatment, and fully realize precision medicine.

neoplasm  /  tumor markers  /  liquid biopsy  /  high-throughput sequencing  /  clinical application