Experimental zoology in China began to develop in the early 1980s. With the rapid development of China's reform and opening up, China's experimental animal science and industry have entered the regular development stage. Genetically modified mice, as an important part of experimental animals, have developed rapidly in China in the past two decades, and have been successively applied in life science and basic medical research, antibody drug evaluation, antibody drug research development and other transformation applications. This review is to expound the development situation of genetically modified mice through the classified statistics and research methods on the six aspects including national investment, institution construction, market development, academic exchange, work focus and achievement accumulation. Finally, this review summarizes the standard establishment process and research development of genetically modified mice in China in the past two decades.

genetically modified mouse  /  genetically engineered mouse  /  genetically humanized mouse  /  fully humanized antibody  /  therapeutic antibody