Irritable bowel syndrome is a functional gastrointestinal disorder, which can affect the quality of children's life and cause mental stress. Defection of the gastrointestinal barrier and imbalance of the inflammatory effect could be the physiopathological mechanism. Research shows that probiotics can improve the function of the barrier and promote the secretion of anti-inflammatory factors. Symptoms are controlled and patients get efficacy in this therapy, but the mechanism and the application of probiotics are currently still under investigation. This review concerns the pathogenic mechanism of IBS, as well as the mechanism, efficacy and safety of the probiotics.

irritable bowel syndrome  /  probiotic  /  IL-10  /  Toll-like receptor  /  strain