Based on the relationship between antibiotics and intestinal flora, this paper summarizes the effects of antibiotics on intestinal flora composition, intestinal colonization resistance, flora and metabolic activities, and then explores antibiotics modulating the intestinal flora to restore the steady state of gut-brain axis or gut-liver axis for delaying the progress of diseases. In the perspective of intestinal flora, the paper briefs the special role of intestinal flora in antibiotic resistance gene storage and transmission, as well as new antibiotic discovery. Further research on the relationship between antibiotics and intestinal flora and their interactions will have a reference value on strategic use of antibiotics or alternative approach development for modulating intestinal flora.

antibiotics  /  intestinal flora  /  antibiotic resistance genes  /  colonization resistance  /  disease