To investigate the suitability of meningococcal groups ACYW135 polysaccharide vaccines for human peripheral blood mononuclear cell (PBMC) in vitro pyrogen test (IL-6), 10 batches of vaccines from different manufacturers are collected. The recovery is determinated by human PBMC-IL-6 in vitro pyrogen test with spiking bacterial endotoxin. The recovery of 10 batches of vaccines is between 50%-200%, and the test solutions are at a dilution less than the maximum valid dilution (MVD). The results show that all the 10 batches of vaccines are qualified products in the pyrogen test. The meningococcal groups ACYW135 polysaccharide vaccine is suitable for the human PBMC-IL-6 in vitro pyrogen test to control the pyrogen.

human peripheral blood mononuclear cell  /  pyrogen test  /  meningococcal groups ACYW135 polysaccharide vaccine