For rare neurologic diseases, a clear etiology is often not available, and one sees a progressive course of the diseases with a diversity in phenotypes, which poses great challenges for the diagnosis and the treatment. Recent years have witnessed a growing role of the precision medicine in dealing with rare neurologic diseases. The precision medicine has shown a great promise in exploring the pathogenesis, refining the diagnosis, improving the treatment and assessing the onset risk. In addition, the precision medicine can serve as the link between the basic medicine and the clinical practice, which provides an innovative model of the disease diagnosis and treatment. Despite difficulties in the resource integration and the omics data integration, the rapid progress of the bioinformatics and the information technology makes more promising the prospect of the precision medicine in dealing with rare neurologic diseases. The precision medical research is expected to have a leap forward in the diagnosis and treatment of neurologic diseases.

rare disease  /  precision medicine  /  neurologic disease