The intracranial aneurysm (IA) is a cerebrovascular disorder in which the weakness in the wall of a cerebral artery or vein causes a localized dilation or ballooning of the blood vessel. The quantitative proteomics is to obtain quantitative information about all proteins in a sample. The quantitative proteomics is mainly performed by isobaric tagging for relative and absolute quantitation (iTRAQ) and 2-DE or mass spectrometry (MS). The identification of the proteins related to the intracranial aneurysm (IA) wall biological activities could help to find novel pathological mechanisms and therapeutic targets for the human intracranial aneurysm. This paper reviews the applications of quantitative proteomics technology in the study of intracranial aneurysm.

cerebrovascular disease  /  intracranial aneurysms  /  quantitative proteomics technology  /  isobaric tagging for relative and absolute quantitation