Electronic nicotine delivery system (ENDS) has the advantage of chemically simple and nicotine contents controllable, and is considered to be the ideal substitute for cigarette. Meanwhile, ENDS is marketed as less harmful alternatives to cigarette because of not burning in the nicotine delivery process and less harmful chemical components in vapor. To deeply study ENDS, DNA damage and mutation caused by tobacco specific nitrosamines (TSNAs) and benzo(a)pyrene in ENDS vapor are reviewed in this paper. Risk evaluation of ENDS in chemical analysis, toxicology, cell exposure, animals experiments and clinical research are also discussed. Finally, the future development of ENDS is prospected.

electronic nicotine delivery system  /  risk evaluation  /  tobacco specific nitrosamines  /  benzo(a)pyrene