Nuclear receptor Rev-erbs have mainly two subtypes, Rev-erbα and Rev-erbβ, which are widely expressed but mainly prevalent in tissues and organs of mammalians that have predominantly metabolic functions. The expression level of Rev-erbs can be influenced by various factors such as high calorie diet, medicine, and exercise intervention. Rev-erbs are essential to regulate glucose and lipid metabolism, insulin secretion, and blood glucose homeostasis, and are the therapeutic target of chronic diseases such as obesity and diabetes. Rev-erbs may maintain energy homeostasis through related signaling pathway of glucose and lipid metabolism. Recent researches indicate that exercise regiments stimulate Rev-erbs expressions in liver and skeletal muscle and maintain lipid homeostasis, which would be the core mechanism of exercise intervention to chronic diseases. This review analyzes the bioactivity and the mechanism of Rev-erbs, and proposes future studies on Rev-erbs in the sphere of sports science.

Rev-erbs  /  energy homeostasis regulation  /  sports science  /  exercise intervention in chronic disease