T lymphocytes play a fundamental role in cellular immune and immune regulation in immune system. However, the overactivation of T cells may induce many diseases including asthma, systemic lupus-erythematosus. It is crucial to control the T cell over-activation in the immunotherapy field. The inhibitory receptors of T cells can regulate proliferation and function of T cells by contacting with their ligands. Latest studies have indicated that T cell inhibitory receptors targeting therapy can attenuate the symptoms of diseases and graft rejection. Intensive study on the regulation of T cells would provide effective strategies for preventing and treating immune diseases.

T lymphocyte  /  inhibitory receptor  /  immune regulation