This paper reviews the antagonism theory and "eighteen incompatible medicaments", as well as the relevant provisions about them in the Pharmacopoeia of China. It provides suggestions for further research concerning the "eighteen incompatible medicaments" through analysis of their historical evolution and the status quo. The incompatibility arguments of the "eighteen incompatible medicaments" are discussed from aspects of literature review, experimental studies and clinical reports. It is found that clinical studies focus on retrospective summary of clinical reports, analyzing clinical safety evaluation and rules of compatible applications. Experimental studies are mostly carried out from aspects of chemical material foundation, pharmacology and toxicology.

"eighteen incompatible medicaments"  /  compatibility of traditional Chinese medicine  /  incompatibility arguments