The serum metabonomic variation in hyperuricemia rats was investigated in order to explore the application of metabonomics in research of hyperuricemia. The animals were divided into two groups at random, i.e., the normal group (n=10) and the model group (n=10). The rat model was treated with yeast extract powder(YEP)as 21 g·kg^-1·d^-1 and OA paired 20 g/L mother liquor with sterile distilled water. The two group's serum was collected and its ¹H nuclear mannetic resonance (¹H-NMR) spectra was acquired. Compared with the normal control group, the model group′s glycoprotein, pyruvic acid, alanine, isoleucine, leucine were all increased, however, formaldehyde, VLDL, unsaturated fatty acid, and acetone were reduced. Significant changes in serum metabonomics found in the hyperuricemia rat models might reflect to a certain extent the pathological changes of hyperuricemia rat models.

hyperuricemia  /  metabonomics  /  rat models  /  ¹H-NMR spectra