To find how the abnormal savda munziq affects the hepatocarcinoma cell morphology of abnormal savda rat, rats were under the stimulations of dry cold environment and dry cold feed and abnormal physical stimulation to establish a model with the abnormal savda according to Uyghur medicine theory. They were raised by sterilized edible water with 0.1 mg/mL of diethylnitrosamine (DEN) solution to establish the hepatocarcinoma model. The rats were treated with high and middle and low doses (6.0, 3.0, 1.5 g/kg) in three groups during the whole period. There were the abnormal savda and HCC model group, low dosage group, middle dosage group, high dosage group, normal control group, and HCC control group, with 24 rats in each group. The animals were anesthetized and killed at the 20th week, then HE staining and observation of morphological characteristics of livers were performed. The results revealed the followings: Albeit no significant differences were found between low dosage group and model groups in morphology, compared with the model groups in high dosage or middle dosage, hyperplasia of connective tissue decreases and the degree of interstitial infiltration of inflammatory cells reduced significantly, cell edema alleviated, reductions of organelle nonuniform, glycogen and mitochondria were significant in the model group. Our findings indicate that the abnormal savda munziq can depress the transformation of hepatocyte to hepatocellular carcinoma in the process of chimeric rats.

Uyghur medicine  /  abnormal savda munziq  /  morphology  /  hepatocarcinoma