Using nuclear magnetic resonance spectroscopy, this paper studies the effect of abnormal savda munziq (ASM) on serum metabolic changes and the mechanism. According to the theory of traditional Uighur medicine, an abnormal savda rat model is established. ¹H-NMR technique is used to determinate serum metabolites in different doses of ASM. After break points, orthogonal partial least-squares discriminant analysis (OPLS-DA) is dopted for pattern recognition analysis of ¹H-NMR spectrum to distinguish changes in metabolic profiling of abnormal savda rat with hepatocarcinoma between the low, medium and high dose groups. Compared with abnormal savda rat with hepatocarcinoma, increased concentration levels of α-glucose, β-glucose, taurine are found in the ASM low dose group. For the serum of rats in the ASM medium dose group, this is also ture while lactic acid is decreased and some essential amino acids are increased. However, no such changes are seen in the serum of the ASM high dose group. Abnormal savda munziq may regulate amino acid metabolism, glucose metabolism such as energy metabolism of abnormal savda rat model with hepatocarcinoma by increasing the content of branched-chain amino acids, accelerating gluconeogenesis to increase energy supply, and reducing accumulation of lactic.

abnormal savda munziq  /  abnormal savda rat model with hepatocarcinoma  /  nuclear magnatic resonance  /  traditional Uighur medicine