At present, a new round of scientific and technological revolution and industrial transformation is advancing at an accelerated pace, with breakthroughs in cutting−edge fields reshaping the global landscape. The scientific and technological development of China during the 15th Five−Year Plan period is not only a crucial stage for itself to achieve the goal of building a world power in science and technology, but also will play an important role in the global pattern of scientific and technological development, exerting a significant and far−reaching impact on the world. How to accurately position itself in the complex and volatile international situation, make forward−looking plans, and scientifically map out the roadmap for scientific and technological development during the 15th Five−Year Plan period is a key issue that China must strive to address at present. In the next 5−10 years, China will face a complex situation where the intensification of strategic games among major powers, the acceleration of scientific and technological industrial transformation, and the arduous task of economic and social transformation are intertwined: science and technology have become the main battlefield of national strength competition, international cooperation has weakened, and security risks have risen; the frontiers of science and technology are advancing in depth, and disruptive technologies are intersecting and integrating, nurturing new industrial forms; China's economy is transforming towards high quality, and security risks in fields such as energy and food are prominent. The construction of a strong science and technology country during the 15th Five−Year Plan period should focus on six aspects: first, strengthen organized basic research; second, coordinate and strengthen the tackling of key core technologies; third, strengthen the dominant position of enterprises in innovation; fourth, promote the integrated development of education, science and technology, and talents; fifth, improve the ecological environment for scientific and technological innovation; sixth, strengthen open innovation and cooperation.