The definition of spatio−temporal Intelligence (STI) is presented, and its characteristics of digitalization, informatization, networking, intelligence, and real−time performance in geomatics, remote sensing, and geographic information science are revealed, as well as its significant position in the field of artificial intelligence. The innovative evolution of STI from positioning, navigation, and timing (PNT) services to positioning, navigation, timing, remote sensing, and communication (PNTRC) services is reviewed and discussed. Furthermore, the application cases of STI in various fields, including the low−altitude economy, public safety and health, autonomous driving and robotics, smart grids and smart factories, forest and grassland monitoring, intelligent management of national parks, and emergency management, are explored. The important role of STI in promoting the development of new quality productive forces is demonstrated.