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Ergothioneine (EGT) is a potent natural sulfur−containing antioxidant with broad application potential in the pharmaceutical, cosmetic, and nutraceutical industries. However, its traditional production methods are inefficient and fail to meet market demand. Recent advancements in synthetic biology offer promising avenues for the efficient bio−manufacturing of EGT. This review systematically summarizes the research progress on using Schizosaccharomyces pombe as a promising chassis organism for EGT production. It focuses on its endogenous biosynthetic capabilities and metabolic engineering strategies, such as promoter engineering, nutrient stress regulation, and mutagenesis screening. We also discuss the major challenges hindering the industrial application of S. pombe, including gaps in fundamental knowledge, unclear physiological functions of EGT, and a lack of standardized analytical methods. Finally, future research directions are proposed, including elucidating the metabolic regulatory network, integrating green production processes, and establishing standardized evaluation systems. This review aims to provide a theoretical foundation for the further development and optimization of S. pombe as a robust platform for EGT synthesis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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