To achieve the "Dual Carbon" goals, industrial biomanufacturing must transits toward green sustainability. Bottlenecks such as high−water consumption, sterilization energy demands, and discontinuous processes have driven the development of next generation biomanufacturing centered on extremophiles (e.g., Halomonas spp.). Their non−sterile open fermentation significantly reduces energy consumption and operational costs. This review highlights Halomonas bluephagenesis as a chassis strain: Through synthetic biology approaches—including the development of specific genetic regulatory tools, optimization of gene editing, accelerated evolution methods, metabolic pathway and cell morphology engineering, Halomonas bluephagenesis has been successfully constructed into an efficient platform. It can utilize diverse and low−cost waste carbon sources (e.g., starch, cellulose, acetate, food wastes) to synthesize biodegradable bioplastics (PHA), high−value small molecules, amino acids, and proteins. Future efforts should focus on developing more versatile synthetic biology toolkits, enhancing the robustness of large−scale fermentation processes, and improving the integration between carbon source pretreatment and process engineering. In conclusion, next generation Halomonas−based biomanufacturing, leveraging the combined advantages of extreme contamination−resistant chassis+synthetic biology tools+process simplification, effectively overcomes inherent limitations of traditional methods. Its significant economic efficiency and environmental compatibility provide crucial support for building a green, sustainable biomanufacturing system and realizing the dual carbon goals.