Preoperative accurate focal localization is a critical determinant of the precision and safety of high−intensity focused ultrasound (HIFU) therapy. Acoustic Radiation Force Impulse (ARFI) imaging and Harmonic Motion Imaging (HMI), which combine therapeutic transducers with acoustic radiation force elastography, have both been proven to improve the accuracy of HIFU therapy, but there remains controversy regarding their performance differences. To address this issue, this study systematically compared the advantages and disadvantages of these two methods through in vitro and in vivo experiments. Porcine longissimus dorsi, bovine liver (in vitro), and live rabbits (in vivo) were used as experimental subjects. ARFI and HMI methods were applied for HIFU focal localization under different parameters, and the localization errors from multiple experiments were quantitatively analyzed. Results across all experimental subjects showed that the average focal error of the traditional geometric localization method was approximately 3−4 mm, while the localization error of ARFI could be stably controlled at around 1 mm, and the error of HMI was close to that of ARFI. However, ARFI technology requires a higher output power, approximately 2−3 times that of HMI. Therefore, ARFI and HMI based on acoustic radiation force elastography can both be used for preoperative HIFU focal localization. Both methods are significantly superior to the traditional geometric localization method in terms of precision, with HMI offering better safety. This study provides important and comprehensive experimental evidence for the clinical application of dynamic acoustic radiation force elastography in HIFU focal localization.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |