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Advances in spaceflight−induced bone loss and China's research progress
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Jingyi SONG1, Cui ZHANG2, Wei QIAN1, Jinfu WANG1, Mengrui WU1, *, Luyang YU1, 2, 3, *
Science & Technology Review | 2026, 44(10) : 43 - 55
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Science & Technology Review | 2026, 44(10): 43-55
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Advances in spaceflight−induced bone loss and China's research progress
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Jingyi SONG1, Cui ZHANG2, Wei QIAN1, Jinfu WANG1, Mengrui WU1, *, Luyang YU1, 2, 3, *
Affiliations
  • 1College of Life Sciences, Zhejiang University, Hangzhou 310000, China
  • 2Lishui Institute of Life and Health Innovation, Zhejiang University, Lishui 323000, China
  • 3Department of Basic Medical Sciences, Harbin Medical University, Harbin 150000, China
Published: 2026-05-28 doi: 10.3981/j.issn.1000-7857.2025.11.00041
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Long−term exposure to microgravity causes significant bone loss in astronauts, posing a major threat to human health and limiting the implementation of deep−space exploration missions. This review systematically summarizes the mechanisms, experimental advances, and major countermeasures related to microgravity−induced bone loss, with a particular focus on relevant research progress in China. Current evidence indicates that weightlessness disrupts the balance between bone formation and bone resorption, characterized by enhanced osteoclastic activity, impaired osteogenic function, abnormal osteocyte apoptosis, and disturbances in calcium metabolism and endocrine regulation, ultimately leading to bone mass loss. Human spaceflight studies, animal experiments, and ground−based simulation models have further revealed the multi−level effects of microgravity on bone structure and function. Although exercise, nutritional supplementation, pharmacological interventions, and mechanical stimulation can partially alleviate bone loss, their protective efficacy remains limited. Future studies should integrate multi−omics approaches with advanced simulation models to further elucidate the mechanisms of spaceflight−induced bone loss and optimize comprehensive countermeasure strategies.

microgravity  /  bone loss  /  osteoblast−osteoclast balance  /  osteocyte  /  ground−based microgravity stimulation models
Jingyi SONG, Cui ZHANG, Wei QIAN, Jinfu WANG, Mengrui WU, Luyang YU. Advances in spaceflight−induced bone loss and China's research progress[J]. Science & Technology Review, 2026 , 44 (10) : 43 -55 . DOI: 10.3981/j.issn.1000-7857.2025.11.00041
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Year 2026 volume 44 Issue 10
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Article Info
doi: 10.3981/j.issn.1000-7857.2025.11.00041
  • Receive Date：2025-11-13
  • Online Date：2026-06-15
  • Published：2026-05-28
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  • Received：2025-11-13
  • Revised：2026-04-22
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Affiliations
    1College of Life Sciences, Zhejiang University, Hangzhou 310000, China
    2Lishui Institute of Life and Health Innovation, Zhejiang University, Lishui 323000, China
    3Department of Basic Medical Sciences, Harbin Medical University, Harbin 150000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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