In recent years, driven by innovation in stem cell theory and technological breakthroughs, relying on the rapid development of engineering technologies such as microfluidics and 3D bioprinting, significant progress has been made in the field of organoid research. The filed of organoid is gradually completing the transformation process from laboratory research to industrialization, penetration into the application markets of biological models, organ transplantation, and biological computing hardware. This paper systematically reviews the global progress in organoid research and development, accurately assessing the current stage of organoid research and industrialization. The study finds that organoid construction has achieved dual breakthroughs in biomimicry and functionality, unlocking new application scenarios, while the industrial system has begun to take shape. On this basis, the study identifies the critical technical bottlenecks and ethical regulatory challenges that urgently need to be addressed in the field of organoid. It further outlines future development directions, including prioritizing new strategies for vascularization and microenvironment simulation, developing novel technologies for in situ monitoring of organoid culture, and formulating supporting ethical regulatory policies and standards. Furthermore, the paper analyzes the current state of organoid development in China from the perspective of three dimensions as the policy support system, the depth of fundamental research, and the competitiveness of industrial chain. Targeted recommendations for high−quality development of organoid in China are then proposed, including: establishing organoid key R&D program, conducting application pilot and demonstrations, improving the standardization system, and designing a tiered governance framework, which aims to provide a reference for leading China toward new heights in the field of organoid.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |