The number of stroke patients in China ranks first in the world. Cryptogenic stroke (CS)，a special type of ischemic stroke, is closely related to patent foramen ovale (PFO). This study focuses on the elderly PFO population at risk of stroke. Through long-term follow-up studies, the aim is to clarify the protective effect and clinical advantages of PFO closure on cerebrovascular adverse events. The endpoint indicators include recurrent stroke/recurrent transient cerebral ischemia, while the remaining indicators include general information and baseline clinical indicators. The follow-up results showed that the incidence rate of cerebrovascular adverse events in the conservative treatment group (5/21, P=0.03) was significantly higher than that in the PFO closure group (1/39) 3 years after treatment. Logistic analysis showed that whether to accept PFO closure was the only independent risk factor for predicting cerebrovascular adverse events in elderly patients with stroke risk (OR=11.562, P=0.003), suggesting that PFO closure surgery can benefit elderly individuals at risk of stroke. Compared with the group receiving PFO closure surgery, the conservative drug treatment group had an 11.562 times higher risk of developing cerebrovascular adverse events in the following 3 years.

elderly population  /  ischemic stroke  /  cryptogenic stroke  /  closure of patent foramen ovale  /  multi-factor analysis  /  prognostic analysis  /  independence influencing factors