Myelosuppression is one of the most common adverse reactions of chemotherapy, which leads to dose reduction, delays, or even interruptions of the treatment.This study adopted a prospective cohort design to collect data from chemotherapynaive patients with solid tumors.Patients were divided into two groups based on whether they continuously used Qi-invigorating and blood-nourishing traditional Chinese medicine (TCM) formulas for at least four cycles during the chemotherapy.The incidence rates of myelosuppression were compared between the two groups.Results showed that the incidence rates of grade 3~ 4 neutropenia, grade 2 or higher thrombocytopenia, and grade 2 or higher anemia were significantly lower in the exposure group compared to the non-exposure group, with all differences being statistically significant (P<0.001, P=0.002, P=0.007, respectively).The study demonstrated that the concurrent use of TCM formulas and patent medicines based on the principles of Qi-invigorating and blood-nourishing during chemotherapy can significantly reduce the incidence of myelosuppression.Qiinvigorating and blood-nourishing therapy can be used as a preventive measure for chemotherapy-induced myelosuppression in solid tumors, applied simultaneously with chemotherapy as a preventive strategy based on syndrome differentiation.

nourishing qi and nourishing blood  /  chemotherapy  /  myelosuppression  /  primary prevention  /  cohort study