Tic disorder is a neurodevelopmental disorder disease that originates in childhood, and more recognized pathogenesis is the dysfunction of the dopaminergic basal ganglion circuit, which is related to a variety of neurochemical and neurotransmitter abnormalities.The drugs currently used for the treatment of tic disorder mainly aim at modulating neurotransmitter imbalances.This article summarizes the recent basic experimental and clinical research on how Chinese and western medicines regulate neurotransmitters in the treatment of tic disorder, and reviews the research status and progress of the treatment, so as to further reveal the pathogenesis of tic disorder and provide a theoretical basis for the clinical application of western medicine in the treatment of tic disorder.The results suggest that the treatment of tic disorder may be related to a decrease in the amount of excitatory neurotransmitters as a whole, as well as an increase in the amount of inhibitory neurotransmitters.However, due to the clinical dispensation of routine cerebrospinal fluid (CSF) and the invasive nature of lumbar puncture, CSF is rarely obtained for neurotransmitter content in children with tic disorder, and the proportion of neurotransmitters across the blood-brain barrier is not clear.It is expected that future studies can further establish a model of the exposure-effect relationship between Chinese and western medicines on plasma, especially cerebrospinal fluid neurotransmitter levels in children with tic disorder, and realize the precise administration of aripiprazole by adjusting the neurotransmitter levels under the guidance of the model.

Chinese and Western medicines  /  tic disorder  /  neurotransmitter  /  aripiprazole  /  cortical-striatum-thalamic-cortical circuit