This article reviews the functional effects of probiotic supplements on human immune system, the molecular biological mechanisms, and the regulatory effects on relative diseases. Probiotics not only constitute an important part of the local immune system of the intestine but also play a two-way immune regulation role in other systems. probiotic supplements can activate the innate immune system of the human body, improving the activity of phagocyte, natural killer cell and other innate immune cells, which can correct intestinal flora imbalance, prevent digestive tract infection and inflammation caused by virus infection, tumor chemotherapy and radiotherapy, improve the body's immunity to influenza and other upper respiratory tract infections, as well as improve the body's anti-tumor immunity; Probiotic supplements can also negatively regulate the specific immune system through activating regulatory T cells, which plays a certain supportive therapeutic role in treating allergic diseases such as food intolerance and asthma, as well as autoimmune diseases such as ulcerative colitis and Krohn's disease.

intestinal probiotics  /  probiotic supplements  /  immune regulation  /  inherent immune system  /  specific immune system  /  viral infection