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Advances of subsequent therapeutic strategies to overcome resistance to CDK4/6 inhibitors in breast cancer and its mechanisms
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Science & Technology Review | 2023, 41(18) : 58 - 66
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Science & Technology Review | 2023, 41(18): 58-66
• Exclusive：Cancer prevention and cure •
Advances of subsequent therapeutic strategies to overcome resistance to CDK4/6 inhibitors in breast cancer and its mechanisms
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MA Jiayi, YIN Wenjin, WU Ziping, LU Jingsong*
Affiliations
    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Published: 2023-09-28 doi: 10.3981/j.issn.1000-7857.2023.18.008
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This article provided an overview of current therapeutic strategies to overcome CDK4/6 inhibitor resistance in breast cancer and analyzed the clinical findings of CDK4/6 inhibitor cross-line therapy, novel oral SERDs, PI3K/AKT/mTOR inhibitors, ADC drugs, AURKA inhibitors, HDAC inhibitors, immunotherapeutic strategies and anti-senescence therapies after CDK4/6 inhibitor progression and the related mechanisms. Furthermore, we prospected the potential targets for clinical studies in the future.
cyclin-dependent kinase 4/6 inhibitor  /  advanced breast cancer  /  mechanisms of drug resistance  /  endocrine therapy
MA Jiayi, YIN Wenjin, WU Ziping, LU Jingsong. Advances of subsequent therapeutic strategies to overcome resistance to CDK4/6 inhibitors in breast cancer and its mechanisms[J]. Science & Technology Review, 2023 , 41 (18) : 58 -66 . DOI: 10.3981/j.issn.1000-7857.2023.18.008
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Year 2023 volume 41 Issue 18
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doi: 10.3981/j.issn.1000-7857.2023.18.008
  • Receive Date：2023-05-26
  • Online Date：2023-09-28
  • Published：2023-09-28
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  • Received：2023-05-26
  • Revised：2023-05-26
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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