Depression (DEP) has become the second greatest threat to human health. In order to evaluate the efficacy of traditional Chinese medicine comprehensive therapy (Jieyu Hehuan Decoction + five element music therapy) on DEP, DEP patients were enrolled and the objective examination of encephaloflocturograph (EFG) and the DEP scoring system were adopted in this study. The indexes include the relative power of brain neurotransmitter based on EFG, Hamilton Depression Scale (HAMD) and Montgomery Asberg Depression Rating Scale (MADRS). The results show that the relative power of γ -Aminobutyric acid decreases (P<0.001) while the relative power of dopamine (P<0.001) and norepinephrine (P<0.001) increase after the therapy, as well as the HAMD (P<0.001) and MADRS (P<0.001). It suggests that the traditional Chinese medicine comprehensive therapy has the proved efficacy on DEP, which produces the anti-DEP effect through the regulation of brain neurotransmitters.

depression  /  encephaloflocturograp  /  traditional Chinese medicine comprehensive treatment  /  neurotransmitters  /  Hamilton depression scale  /  Montgomery asberg depression rating scale