Tumor immunotherapy has become the fourth type of tumor therapies after surgery, radiotherapy and chemotherapy, and a hot field of international research. Nowadays, we have entered the era of tumor immunotherapy, and immunotherapy represented by immune checkpoint inhibitors and genetically engineered immune cells is a promising therapy for cancers. This article summarizes the hot topics and key advances in cancer immunotherapy in 2022, including the breakthrough of chimeric antigen receptor T cells (CAR-T) in the treatment of solid tumors, the discovery of a new mechanism to maintain survival and function of memory T cells, the in-depth exploration of tumor immunosuppressive microenvironment to improve the efficacy of immunotherapy, and the important influence of intratumoral microbiota on immune responses against tumor.

tumor immunity  /  CAR-T cells  /  memory T cells  /  tumor immunosuppressive microenvironment  /  intratumoral microbiota