The bifunctional reaction of styrene derivatives with alcohols, ketones, nitriles, ethers, thioethers and other solvent molecules is a radical relay reaction discovered and developed by Wang Naixing's research group since 2012. A persistent and stable radical (free radical on the carbon atom adjacent to the benzene ring) is generated during the reaction duo to the p-π conjugation effect of the benzene ring, this reaction is called thes Wang reaction since 2018. This effective reaction can realize the high value conversion of the styrene derivatives through one-step reaction, which is of great significance for the new synthesis methods of drugs and intermediates.

bifunctional reaction  /  radical relay reaction  /  p-π conjugation effect  /  synthesis methods