The third-generation vaccine technology represented by mRNA vaccine has played a important role in the fight against the novel coronavirus pneumonia (COVID-19). The technique of modifying mRNA with pseudouridine and its analogs developed by Katalin Karikó and Drew Weissman is the key basis for the successful development of mRNA vaccine. The scientific research road of the main pioneer of this technology, Katalin Karikó, and the research and development of the mRNA COVID-19 vaccines provide us with much food of thought. Karikó's success is inseparable from her firm belief in face of difficulties and the spirit of persistently and steadfastly engaging in basic research. One should pay more attention to the key role of basic research in promoting the source innovation.

mRNA  /  vaccines  /  Katalin Karikó  /  basic research