The recombinant DNA technology was developed by a university laboratory in the U.S in 1972.The Recombinant DNA Advisory Committee (RAC) was established by the government of U.S in 1974 and played a significant role in regulating the risks of gene manipulation technology until 2019.With the ups and downs of RAC in the course of risk regulation of gene manipulation technology in the U.S,the technical risk regulation of gene manipulation technology in the U.S has gradually developed from infant to mature.This article depicts the roadmap for the RAC and its regulatory power to come into being,retrieves the contributions that RAC made to regulating the technical risks under the haze of gene manipulation technology risks with plenty doubts from government authorities,and presents the basic regulation of gene therapy in the United States.The article also narrates the critical event of the gene therapy,including the process of the first case with RAC's approval and the performance of RAC facing the first fatal case.

gene editing  /  Recombinant DNA Advisory Committee  /  gene therapy  /  risk regulation