The colorectal cancer is one of the most common digestive tract tumors globally, which seriously threatens the human health. In recent years, a gratifying progress has been made in the organoid culture technology, making the organoid technology an essential new tool for studying the colorectal cancer mechanisms and the clinical translation. This paper reviews the niche signaling pathways in the colorectal cancer, the application progress of the organoid technology in the colorectal cancer modeling, the tumor microenvironment research, the drug screening and the individualized therapy, as well as the current challenges of the organoid technology and the future development directions of the organoids from the perspectives of the organoid culture technology standardization and the engineering technology applications.

organoids  /  colorectal cancer  /  stem cell niche  /  tumor microenvironment  /  Wnt signaling