Micro/nanomotor drug delivery technology is a new drug delivery mode in vivo based on the self-motion of the drug carrier, which can promote the effective enrichment, retention and penetration of the therapeutic drugs in the lesion site in a nondestructive mode. Its high performance encourages the scientific community to make more effort to accelerate the development of micro/nanomotor in the biomedical field, to find a new way to solve some important traditional biomedical problems at the micro/nano-level, and to establish new principles of the disease treatment and the possible application models. This paper reviews the research progress of micro/nanomotor drug delivery technology, including the drug delivery mode, the drug loading mode, the targeting ability of the micro/nanomotor drug delivery system, the drug delivery movement of micro/nanomotor in the physiological environment, the promotion effect of the autonomous movement of micro/nanomotor in improving the cell uptake and the tissue permeability, and the drug delivery mechanism of micro/nanomotor. Finally, the future development trend of this field is prospected.

micro/nanomotor  /  drug delivery  /  targeting  /  cell uptake  /  tissue permeability  /  disease treatment