To study the hypoglycemic effects of jackfruit oligopeptides in db/db diabetic mice, 48 db/db diabetic mice are randomly divided into six groups (with 8 mice in each group):three jackfruit oligopeptides groups (with 0.2 g/kg·bw, 0.4 g/kg·bw and 0.8 g/kg·bw JOPs, respectively, by intragastric administration), a diabetic model group, a metformin control group (with 0.2 g/kg·bw metformin hydrochloride enteric-coated tablets aqueous solution by intragastric administration) and a whey protein control group (with 0.4 g/kg·bw whey protein aqueous solution by intragastric administration), while 10 db/m mice are used as the blank control for non-diabetic mice. The fasting glucose, the OGTT-AUC, the liver glycogen and the muscle glycogen are measured during the intervention. It is shown that the JOPs could decrease the fasting blood glucose and the OGTT-AUC in the diabetic mice (P<0.05), especially in the 0.4g/kg·bw-dose group. The long-term jackfruit oligopeptides intervention can effectively reduce the blood glucose level and improve the glucose tolerance of diabetic mice.

jackfruit oligopeptides  /  hypoglycemic  /  glucose tolerance  /  db/db diabetic mice