Changes in serum hormones, carcinoembryonic antigen (CEA) and islet function index levels before and after insulinoma resection are explored. It is found that from day 1 to day 5 after the operation, the patients' homeostasis model assessment-β (HOMA-β) and insulin sensitivity index (ISI) decrease, insulin resistance index (homeostasis model assessment of insulin resistance, HOMA-IR) and blood glucose levels increase, and CEA level increases first and then decreases. The difference is statistically significant (P<0.05). Compared with day 5 after the operation, patients' HOMA-β and ISI levels increase and HOMA-IR levels decrease from day 10 to day 15 after the operation; insulin levels are 14.16±3.06 μU/L, but significantly lower than those before the operation, the blood glucose level drops to 4.62±0.31 mmol/L, which is significantly higher than 2.12±0.59 mmol/L before the operation. There is no significant change in CEA index and the difference is not statistically significant (P>0.05). There is significant correlation between CEA level and various indicators. Pancreatic islet function indicators, serum hormones and CEA levels can cause an abnormal decrease in insulin levels and a sharp increase in blood glucose levels within a short period of time after surgery, which can be used as prognostic indicators.

insulinoma resection  /  islet function index  /  serum hormone  /  carcinoembryonic antigen