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Advances in research of POLE/POLD1 mutations in cancer immunotherapy
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Science & Technology Review | 2021, 39(7) : 38 - 47
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Science & Technology Review | 2021, 39(7): 38-47
• Exclusive: Tumor Markers •
Advances in research of POLE/POLD1 mutations in cancer immunotherapy
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MAI Zongjiong, PU Hengying, WANG Feng
Affiliations
    Department of Medical Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
Published: 2021-04-13 doi: 10.3981/j.issn.1000-7857.2021.07.004
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This article expounds the involvement of subunits encoded by DNA polymerase (POLE) and DNA polymerase delta 1 (POLD1) in DNA replication and proofreading, summarizes the effects of POLE/POLD1 mutations on tumor mutation load and intratumoral immune cell infiltration, and reviews the research progress of POLE/POLD1 mutations in immunotherapy of endometrial cancer, colorectal cancer and lung cancer. This article also discusses the challenges faced by POLE/POLD1 mutations as potential molecular markers for the predicting efficacy of immune checkpoint inhibitors.
POLE  /  POLD1  /  mutation  /  immunotherapy  /  biomarker
MAI Zongjiong, PU Hengying, WANG Feng. Advances in research of POLE/POLD1 mutations in cancer immunotherapy[J]. Science & Technology Review, 2021 , 39 (7) : 38 -47 . DOI: 10.3981/j.issn.1000-7857.2021.07.004
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doi: 10.3981/j.issn.1000-7857.2021.07.004
  • Receive Date：2020-07-21
  • Online Date：2021-05-13
  • Published：2021-04-13
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  • Received：2020-07-21
  • Revised：2021-01-19
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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