The title compound spiro[indoline-3,3'-pyrrolizin]-2-one C₂₇H₂₄ClN₃O₂ is synthesized by the one-pot multicomponent reaction of chalcone, 5-methylisatin and proline in trace amounts of methanol under stirring at 60℃. Its structure is determined by single crystal X-ray diffraction. The crystal is monoclinic, space group P₂(1)/c, with M_r=504.01, a=0.84907(6) nm, b=1.07072(9) nm, c=2.9121(4) nm, V=2.6415 (5) nm³, Z=4, D_c=1.267 mg/m³, μ=0.180 mm^-1, and F(000)=1064. The structure is solved by direct methods and refined by full-matrix least squares method to the final R=0.0657 and ω_R=0.1376. X-ray analysis reveals that the newly formed ring of tetrahydropyrrole in the crystal structure is of envelope conformation.

spiro[indoline-3,3'-pyrrolizin]-2-one  /  multicomponent reaction  /  crystal structure