Amphotericin B, as the first drug against deep fungal infection which has been used for more than fifty years, is still an indispensable antibiotic in clinical treatment. In recent years, with the development of AmB derivatives, the analysis of genome of the Streptomyces nodosus and the metabolic pathways of AmB, more and more strategies involving genetic engineering and metabolic engineering were used to study the combinatorial biosynthesis of AmB. It's obviously AmB paly an important role in clinical treatment, for this reason developing the production of AmB has significant economic and social benefits. Herein, a brief summary of AmB, the organization of the AmBiosynthetic gene cluster and its current combinatorial biosynthesis is reviewed.

amphotericin B  /  Streptomyces nodosus  /  synthetic gene cluster  /  combinatorial biosynthesis