Recent studies show that for the type 2 diabetes the Parkinson's disease is more likely to be developed than for normal diabetes, and the 1-acetyl-6, 7-dihydroxyl-1, 2, 3, 4-tetrahydroisoquinoline (ADTIQ) could be a key factor associated with the diabetes and the PD. In the present study, the SH-SY5Y cells are used as a model to investigate the ADTIQ generated conditions. It is found that the hyperglycemia could induce the increase of the endogenous methylglyoxal, which might react with the dopamine to generate the ADTIQ. Again, the hyperglycemia leads to a reduction of the dopamine in the SH-SY5Y cells and the plasma of the type 2 diabetic rats, and an increase of the tyrosine hydroxylase (TH) and the dopamine transporter (DAT). So, the hyperglycemia induces the generation of the ADTIQ and the dopamine metabolism imbalance. The generation of the ADTIQ could play a key role in increasing the risk of the PD in patients with diabetes.

1-acetyl-6, 7-dihydroxyl-1, 2, 3, 4-tetrahydroisoquinolin  /  diabetes  /  Parkinson's disease  /  dopamine