To explore the therapeutic effect of HaizaoYuhu decoction with or without seaweed and liquorice anti-drug combination on goiter rats, Wistar rats were randomly divided into 7 groups. The blank group were gavaged normal saline, the other groups were fed propylthiouracil copy goiter model,with the Euthyrox as a positive control drug. Continuous administration of drugs was used once a day for 28 days To detect the thyroid coefficients, T₃, T₄, FT₃, FT₄, TSH and TRH, the thyroid tissue morphology in each group was observed by HE staining. The result showed that the thyroid coefficients of each group are lower than those of the model group and have a significant difference (P<0.05). Compared with the model group, T₃ and T₄ of each group have a trend of increase but no significant difference. TSH of each group decreases obviously and has a significant difference (P<0.05). Compared with the model group, TRH of full formula group decreases obviously and has a significant difference (P<0.05), full formula group without seaweed, full formula group without liquorice, full formula group without seaweed and liquorice have a trend of decrease but no significant difference. According to the result, Haizao Yuhu decoction full formula group can better recover goiter and callback indicators in preferred compatibility proportion conditions than full formula group without seaweed, full formula group without liquorice, and full formula group without seaweed and liquorice.

Haizao Yuhu decoction  /  anti-drug combination  /  goiter