As metallomics becomes a focus area in recent years, the related research approaches are getting a rapid development. Especially for the nuclear analysis techniques, such as isotope dilution (tracer) technique, synchrotron radiation X ray fluorescence analysis (SR-XRF), and synchrotron radiation X ray absorption spectroscopy (SR-XAS) techniques, combined with other biochemical separation and analysis techniques like electrophoresis, high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS), electrospray ionization mass spectrometry (ESI-MS) and so on, they have been widely used for the function and interaction research of Hg and Se in bio-organisms. Selenium (Se) is one of the essential trace elements for human and animals, and can apparently antagonize the toxicity of heavy metals such as mercury (Hg). To analyze the distribution and speciation of Se and Hg in organisms, to get a insight into their absorption, transformation and accumulation in different tissues, and to further explore the potential roles of Se on the bio- effects of Hg in organisms is quite crucial for the control of Hg pollution and the acquaintance with Hg-Se interaction in bio-organisms. Based on the previous reports and the results from our lab, the present work will give an informative review about the metallomics approaches as applied in the research of Hg, Se interaction in bio-organisms.

mercury  /  selenium  /  metallomics  /  nuclear analytical method