To study the protective effect of trinosin on the liver of chronic mountain sickness (CMS) rat model, CMS was induced in 50 of 60 SD rats,which were randomly divided into CMS model group, nifedipine control group, high, medium, low dosage trinosin groups and blank control group (10 each). Fifty rats were in low pressure oxygen cabin for 30 days except for the blank control group. After continuous gavage administrationfor 15 days according to their weights,we tested the indexes of pulmonary artery pressure (PAP), homocysteine (Hcy), interleukin- 6 (IL- 6), C- reactionprotein (CRP), superoxide dismutase (SOD), malondialdehyde(MDA), glutathione peroxidase (GSH- PX), alanine aminotransferase (ALT), and aspartate transaminase (AST). The results showed that compared with the blank control group, the CMS model group and nifedipine control group had higher levels of PAP, Hcy, IL-6, CRP, MDA, ALT and AST (P < 0.05), but lower levels of SOD and GSH-PX (P < 0.05), indicating the rat liver was damaged under hypoxic condition. Compared with the CMS model group, the high dosage trinosin group had lower levels ofHcy, IL-6, CRP, MDA, ALT and AST (P < 0.05), but higher levels of SOD and GSH-PX (P < 0.05), indicatinghigh dosage of trinosin had protective effect on the liver of CMS rat model.

trinosin  /  liver  /  chronic mountain sickness